Hmmm.. I guess it depends on the opposition. Get ball forward increases the passing range and the tempo. Maybe it's not good for some games, when you're leading for 1-0 and need to keep the ball. For example, if you use "push higher up" but don't penetrate in opposition, it's good to untick that shout to make the other team leave their's midfield and then you can bang them in counter-attack. In other example, Mike suggests other combo: drop deeper, retain possession and pass into space. Makes the same effect. You have to read about the shouts and keep an eye on the match and see what happens and then decide.
As for the players (you're Madrid I guess) I'll use that combo (dlp+anchor men), AML (Ronaldo as IF), AMC (Ozil, Kaka as Attack'in midfielder), Di Maria as Right Midfielder to provide some security (Defensive Winger), and Benzema or Higuain as Poacher. If use Modric I think the best role is in the MC spot as Advanced Playmaker and then Di Maria play in AMR (IF)
This is my opinion...

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