I struggled for a long time trying to make Liverpool win the EPL. I knew I needed to have an awesome tactic to be able to do so, and I tested most of the most the "promising" tactics out there without any luck, so I started working on this. Now, after a lot of work, it's finally stable, and with this tactic you can win the EPL playing Liverpool the first season.
After what I hear from others who have tested it, it works with most teams. It's a creativity-based 4-5-1, where you will see some beautiful football played, and it is actually very stable in the back too, because of the constant pressure on the opposition. If you play this with a top team you will probably not have any losses at all. If you play a mid-table team like Liverpool, you have a good chance of winning the EPL.
It's a plug and play tactic, no modifications needed. If you are struggling to score at home (always wait until after half time), you can set it to "attacking", but I wouldn't advise this in away matches.
Players: See the different roles
Most important players: Advanced Playmaker (MC), Wingers and Poacher. It's very good if you have a poacher who is strong as well, as he will get a lot of crosses from the wingers. The advanced playmaker needs to have good creativity, decisions and passing, but I'm sure I don't have to tell you that
Match prep: Attacking movement if you have a strong team, Defensive positioning if you have a weak team
Team Talk: Been using assistant manager to do that
When game starts, use match prep: tactics only, together with team cohesion, 50/50 until your first league match. Then change to Balanced/Defensive Positioning/Attacking Movement.
The tactic also works with Complete Forward instead of Poacher, but then you are much more reliable on the wingers and CM's finishing skills, and very few clubs have a good complete forward anyway (No, Suarez is not a good CF).
The tactic works just as good in 13.2.1 btw.
Good luck to anyone who tries it
UPDATE: I HAVE NOW MADE A 4-2-3-1 version of the tactic as well, that seems to do even better in my games. I haven't tried it with weak teams, but it looks really promising. If you have a strong team, definitely use the new 4-2-3-1 tactic. After some feedback from testers, it seems the 4-5-1 version is better for weaker teams, and lower league teams.
Download link for the 4-2-3-1 tactic:
Spin the Wheel 4-2-3-1 (Godlike version)